Marcus InstituteSection Title

Clinical Trials

Research at the Marcus Institute is an essential component as we feel it is necessary to evaluate all aspects of integrative medicine. Importantly, we are trying to link clinical effects such as reduced pain or improved function with physiological changes measured using state-of-the-art imaging techniques. Specifically, we utilize the regions only PET-MR scanner for adults in order to determine structural and functional changes associated with various integrative therapies for neurological and psychiatric conditions as well as specific diseases such as cancer or irritable bowel syndrome.

Clinical Trials

Our studies include the following:

Current Projects

  • Physiological Effects of Nutritional Support in Patients with Parkinson’s Disease: This study explores the impact of NAC in patients with Parkinson’s disease and evaluates neurophysiological changes in response to NAC utilizing Datscan imaging.
  • Physiological Effects of N-Acetyl Cysteine in Patients with Multiple Sclerosis: This study explores the impact of NAC in patients with multiple sclerosis and evaluates neurophysiological changes in response to NAC utilizing FDG PET-MRI.
  • The Neurological Correlates of Creativity: This study is designed to use fMRI to explore brain function in individuals who are highly creative within a variety of fields including business, music, education, mathematics, psychology and engineering.
  • Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) Study: PET-MRI imaging site for a nation-wide study of the use of amyloid PET imaging in patients with cognitive impairment.
  • Evaluation of MBSR Program in the Elderly Using fMRI: This study is evaluating the effects of the MBSR program on brain function using fMRI in an elderly population.
  • Use of a Functional Neuroimaging Battery for the Evaluation of a Meditation Practices: Study supported by the Fetzer institute to evaluate meditation program using fMRI and Datscan imaging.
  • Desensitizing Distressing Recollections in Cancer Patients: This study uses fMRI to explore the neurophysiological effects of the NeuroEmotional Technique intervention in cancer patients with distressing memories related to their cancer diagnosis.
  • A Pilot Study of Intravenous Ascorbic Acid and FOLFIRINOX in the Treatment of Advanced Pancreatic Cancer: This study utilizes intravenous vitamin C with chemotherapy in patients with pancreatic cancer.


Upcoming Projects in 2017

  • Defining Neurobiological Signatures for Chronic Traumatic Brain Injury Using PET-MRI Technology: This study is developing a PET-MRI imaging battery for patients suffering from chronic concussion symptoms and will be used to evaluate integrative medicine approaches for the treatment of these patients including the use of n-acetyl cysteine.
  • Physiological Effects of an Integrative Medicine Approach in Irritable Bowel Syndrome: This study will evaluate inflammation in the gut using FDG PET-MRI in patients with IBS and will evaluate the effects of integrative medicine therapy.
  • PET Imaging Pre and Post Chiropractic Therapy for Chronic Pain Syndromes: This study will explore the physiological effects in the brain and body of chiropractic therapy in patients with chronic pain using FDG PET-MRI.
  • Pilot Study Using PET-MRI in Patients with Insomnia With An Integrative Intervention: This study will explore the neurophysiological correlates of insomnia and how they are modified by therapy using acoustic and vibratory stimulation.

Marcus Institute
Of Integrative Health